Telomeres, DNA sequences at the stop of chromosomes that shorten as cells replicate and age, does not normally correlate with chronological age, and there is proof to suggest telomere shortening may perhaps be modifiable by lifestyle variables.
“The factors that are strongly involved with accelerated telomere shortening and dysfunction are oxidative strain and swelling,” explained scientists from Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences in Nutrients.
“The skill of omega‐3 fatty acids to reduce these adverse effects is relevant not only to their well‐documented effective influence on a selection of ‘lifestyle’ illnesses but also to their useful effects on telomere biology.
“The use of omega‐3 fatty acids to reduce accelerated telomere attrition and, for that reason, counteract untimely growing older and minimize the hazard of age‐related health conditions raises high hopes.”
The growing old and lifespan of usual, healthful cells are joined to the so-called telomerase shortening mechanism, which limitations cells to a set amount of divisions. In the course of cell replication, the telomeres perform by making sure the cell’s chromosomes do not fuse with each other or rearrange, which can guide to most cancers.
Elizabeth Blackburn, a telomere pioneer at the University of California San Francisco, likened telomeres to the ends of shoelaces, without which the lace would unravel.
With each and every replication the telomeres shorten, and when the telomeres are entirely consumed, the cells are wrecked (apoptosis). Telomere shortening or attrition was shown as a person of the nine hallmarks of growing old in a seminal paper published in Cell in 2013 by Carlos López-Otín et al.
“One element inversely linked to telomere length is serious strain, both during the prenatal period and childhood, as perfectly as in grownup daily life,” wrote the Poland-primarily based researchers in Nutrients. “Depression, smoking, obesity, and alcoholic beverages use also speed up telomere attrition.
“Interestingly, dietary restriction and raising nutritional antioxidants protect in opposition to telomere shortening. In this context, omega‐3 fatty acids are crucial nutritional compounds that, owing to their biochemical attributes, might influence the biology of telomeres.”
Their new critique of the scientific literature incorporated 7 observational (non-interventional) scientific studies, which indicated that, in normal, omega-3 fatty acids may enjoy a part in telomere biology. These effects, however, merely demonstrate correlation and not causation, which has led researchers to execute randomized dietary scientific tests utilizing omega-3 dietary supplements.
The Poland-based scientists noted 4 such intervention experiments, which ended up carried out in a array of populations, like mothers and their infants, individuals with chronic renal impairment, older individuals suffering from moderate cognitive impairment, and balanced, obese, middle‐aged and aged individuals. Doses applied ranged from just in excess of a person gram for every working day to 4 grams for every day of omega-3 fatty acids.
The info from the randomized trials were being a mixed bag, with some indicating a potential benefit and other individuals locating no consequences.
The reviewers also searched the scientific literature for info from animal scientific tests, and observed a few scientific studies that showed a profit from omega-3 supplementation of the diet program.
“While the success of the presented cross‐sectional and randomized human and rodent reports are not completely dependable, the too much to handle amount of them have demonstrated the valuable effects of omega‐3 fatty acids on telomere duration,” wrote the reviewers.
Limits and what’s upcoming?
Even with the evidence staying generally supportive of a part for omega-3 fatty acids to protect from telomere attrition, the reviewers famous that sample dimensions from some scientific tests have been tiny, though also noting that telomere length in leukocytes, which is the most important measurement utilized in the experiments, could be diverse to telomere duration in other tissues.
“… discrepancies in the presented results however suggest the need for a very careful evaluation of the style of omega‐3 fatty acids, their origin, dose and the timing of administration, as properly as age, gender, regional and ethnic range, and health and fitness status,” concluded the reviewers.
2022, 14(18), 3723 doi: 10.3390/nu14183723
“Effect of Omega-3 Fatty Acids on Telomeres—Are They the Elixir of Youth?”
Authors: M. Ogłuszka, et al.